Histopathological diagnosis revealed a canalicular adenoma of the parotid gland. Title canalicular adenoma arising in the upper lip. Hepatocellular carcinoma hcc is currently the sixth most common type of cancer with a high mortality rate and an increasing incidence worldwide. When seen in isolation in small biopsies, these features may lead to confusion. Report of a rare case ezher hamza dayisoylu,1ali alper pampu,2sevdegul mungan,3fatih taskesen4 department of oral and maxillofacial surgery, faculty of dentistry,1,2,4department of pathology, faculty of medicine,3 karadeniz technical university, trabzon, turkey. Canalicular adenoma is a rare benign salivary gland tumor of the oral cavity, typically located in the upper lip and buccal mucosa and infrequently found on the palate. It is a rare entity, representing less than 1% of salivary gland tumors 2.
If something happens to either interrupt the excretion into the canalicular spaces or the flow of bile through the biliary system, youll have backup of the bile. Their incidence peaks during the seventh decade of life. Despite its benign nature, some patients may present multiple nodules and also microscopic growth that can be multifocal with foci of tumor within the adjacent gland. Overall, pleomorphic adenoma is the most frequent sgt, comprising about 5060% of cases. Histopathology ancillary studies histochemical, immunohistochemical, ultrastructural, molecular, and genetic differential diagnosis precursor lesions. Diagnostic difficulties in lesions of the minor salivary glands. Histopathologic features of hepatocellular carcinoma. Canalicular adenoma is a benign neoplasm of the salivary glands. Canalicular adenomas are benign neoplasms with a unique predilection for the upper lip 80% of cases. Department of pathology and stomatology, alfenas dentistry and pharmacy. All basal cell adenoma variants exhibit some degree of myoepithelial cell. Histopathology for the diagnosis of infectious diseases e gupta, p bhalla, n khurana, t singh abstract histopathological examination of tissue biopsies for the identification of infectious organisms is a very important diagnostic tool.
Clostridium piliforme rodents, immunocompromised or young foals, calves, kittens, puppies lesions multifocal necrotizing hepatitis. Ductal adenomas of salivary gland showing features of striated duct differentiation striated duct adenoma. Report of a rare case ezher hamza dayisoylu,1ali alper pampu,2sevdegul mungan,3fatih taskesen4 department of oral and maxillofacial surgery, faculty of dentistry,1,2,4department of pathology, faculty of medicine,3. Canalicular adenomas are rare benign tumours of the salivary. Aug 21, 2014 there is a lack of a comprehensive immunohistochemical ihc analysis of canalicular adenoma canad, especially when combined with a description of the unique histologic features. There is some disagreement among investigators about whether canalicular adenoma should be included within the basal cell adenoma histologic spectrum. To describe a salivary adenoma composed largely of unilayered ducts resembling striated ducts, and to differentiate it from similar adenomas, including canalicular and. Immunohistochemical profile of canalicular adenoma of the upper lip. Gpc3, an oncofetal protein that is not found in hepatocellular adenoma but may be present in hcc and dns and has been reported in chronic hepatitis c. These cells are a characteristic feature of pleomorphic adenoma. This can occur either within the hepatocytes \l\ or within the ca\ nalicular spaces \r\. All structured data from the file and property namespaces is available under the creative commons cc0 license. Canalicular adenoma is a benign neoplasm of a salivary glands which originally was considered to be a variant of basal cell adenoma.
Canalicular adenoma is a rare benign salivary gland tumour usually noted in elderly patients. Distinct monomorphic adenoma with bilayered strands or ribbons of columnar cells with pure luminal ductal epithelial differentiation and loose. Fibroadenoma of the breast is a benign tumor composed of a biplastic proliferation of both stromal and epithelial components. Teller, md the university of texas medical branch, department of otolaryngology grand rounds presentation. Given the usual small biopsies, ihc may be useful in distinguishing canad from other tumors in the differential diagnosis. Pdf canalicular adenoma arising in buccal mucosa researchgate. It has a greater tendency to involve the minor salivary glands.
The most common site of occurrence is the upper lip. Canalicular adenoma ca is a benign epithelial salivary gland neoplasm characterized by chains of columnar epithelial cells arranged in thin anastomosing cords with a beaded pattern and preference for minor salivary glands, most probably originating from excretory duct cells. Department of oral and maxillofacial pathology, nims dental. We report a case of canalicular adenoma in the upper labial mucosa of a male patient, highlighting the clinical and histopathological differential peculiarities compared to other lesions of similar location.
Canalicular adenoma ca is an uncommon, benign salivary gland tumor that was described by the world health organization classification in 1991. Mar 07, 2018 what is the prognosis of a canalicular adenoma of salivary gland. May 29, 2019 adenoma is a non cancerous tumor that begins in the epithelium of mucosa or in the glands and ducts of the endocrine hormone producing glands or exocrine glands like sweat glands and glands in. The second most frequent benign sgt is warthin tumor. The risk factors include radiation exposure, familial predisposition. At followup the lesion had increased in size and an excisional biopsy was arranged. Definition canalicular adenoma is a benign salivary gland tumour composed of monomorphous epithelial ductal cells arranged in anastomosing cords within cellpoor vascular stroma. Basal cell adenoma of the lung identified with obstructive. Health, general adenoma development and progression diagnosis. To report a case of canalicular adenoma ca and discuss the use of immunohistochemistry to better address the diagnosis given some unusual characteristics in this patient. Initial histopathology demonstrated the lesion to be fibrofatty tissue and the lesion was monitored over a 6month period. This biplasia can be arranged in two growth patterns. The present report describes a case of an 85yearold woman who underwent an excisional biopsy of a preauricular lesion centred over the zygoma and subsequently developed an immediate iatrogenic facial palsy. Canalicular adenoma ca is an uncommon benign salivary gland tumor that mostly occurs in the upper lip.
Other locations arebuccal mucosa, the palate and the parotid gland. Originally thought to be derived from terminal duct origin 1, 2, there has been controversy about origin and separation from other salivary gland neoplasms. Canalicular adenoma definition of canalicular adenoma by. Hcc is more common in males than in females and mostly occurs in developing countries. Canalicular adenoma is a benign, epithelial salivary gland neoplasm arranged in interconnecting cords of columnar cells. Introduction neoplasms of the major salivary glands constitute minor portion of head and neck neoplasms less than 2% are malignant most neoplasms in parotid 75%. Ca is an uncommon benign neoplasm that can develop in minor salivary gland duct tissues throughout the oral cavity. Canalicular adenoma ca is a benign tumor that develops in the. Introduction canalicular adenoma ca is a benign salivary neoplasm that primarily affects minor salivary glands 1. Patients usually present with a welldefined painless swelling in front of or behind the ear parotid tumors. Canalicular adenoma is also a benign neoplasm composed by columnar cells arranged in branching and interconnecting cords of single or double cell thick rows.
Clinical and histological features of multifocal canalicular. Hepatocellular carcinoma hcc is the sixth most common type of cancer and with about 9. Adenoma is a non cancerous tumor that begins in the epithelium of mucosa or in the glands and ducts of the endocrine hormone producing glands or. Fundamental liver pathology part 1 duke university. It is most common in the 7th decade of life but can occur from 4th to 9th decades of life. Histopathology 57, 707715 ductal adenomas of salivary gland showing features of striated duct differentiation striated duct adenoma. Sgts of the tongue, floor of the mouth and retromolar areas are most often malignant. Henry ford hospital, detroit, mich, and the university of. Ductal adenomas of salivary gland showing features of. The cystic lesion has a mildly fibrotic appearing wall, is lined by histiocytes intermixed with rare lymphocytes, and contains mucous and macrophages.
Aug 21, 2014 canalicular adenoma canad is an uncommon benign salivary gland neoplasm. The sections show a stratified squamous epithelium with a thin layer of parakeratosis, minor salivary glands, and a wellcircumscribed cystic lesion. Salivary gland basal cell and canalicular adenomas allen press. Therefore, the pathological diagnosis of bca, which was mainly composed of basal cells accompanied by luminal and myoepithelial cells in our case, was valid and feasible. Epidemiology canalicular adenomas occur in the fourth to seventh decades of life and rarely before the age of 50 years. Histopathology showed that the tumor was an encapsulated mass with a complex. Files are available under licenses specified on their description page. It is a relatively rare neoplasm, but it is the second or the third most common tumor among benign tumors of minor salivary glands 4, 5. What is the prognosis of a canalicular adenoma of salivary gland.
Woodland hills medical center, department of pathology. Hcc most commonly occurs on ground of a cirrhotic liver but interestingly an increasing proportion of hccs develop in the nonfibrotic or minimal fibrotic. They occur over a wide age range but the peak incidence is in 6th to 7th decades with a slight female predominance. They account for 1% of all salivary gland neoplasms. This is a very rare benign neoplasm, that makes up about 1% of all salivary gland tumors, or about 4% of all benign salivary gland tumors. A typical example with ductal structures and tubules canals lined by a single layer of basophilic columnar cells. Canalicular adenoma benign salivary gland neoplasm composed of bilayered strands of basaloid cells that branch and anastomose to form variably sized channels canaliculi. Diagnostic difficulties in lesions of the minor salivary. Introduction canalicular adenoma ca is a distinctive tumor occurring almost exclusively in the upper lip. Conventional culture confirmation of tissue biopsies often fail to identify any pathogen as, first of all. The histopathology of the salivary glands, and particularly of salivary gland tumours, is complex and may be problematic for.
Immunohistochemical aspects of basal cell adenoma and. Salivary gland basal cell and canalicular adenomas archives of. Carcinoma expleomorphic adenoma prognostic factors pathologic stage size histologic grade and type proportion of carcinoma extent of invasion ki67 labeling index canalicular adenoma benign salivary gland neoplasm composed of bilayered strands of basaloid cells that branch and anastomose to form variably sized channels canaliculi age. There is a lack of a comprehensive immunohistochemical ihc analysis of canalicular adenoma canad, especially when combined with a description of the unique histologic features. The risk of tumor recurrence following surgery is minimal. Ca has a significant predilection for occurrence in the minor salivary glands, with most cases occurring in the upper lip, followed by the buccal mucosa and palate 15. Canalicular adenoma is an uncommon benign salivary gland neoplasm that has. Keywords canalicular adenoma 4 lip 4 buccal 4 palate 4. Canalicular adenoma ca is an uncommon benign salivary gland tumor that mostly. Outcomesresolutions the prognosis of canalicular adenoma of salivary gland is generally excellent with surgical intervention and complete removal, since it is a benign tumor.
Fundamental liver pathology part 1 diana cardona, md june 15, 2011. Canalicular adenoma canad is an uncommon benign salivary gland. Well circumscribed, lobulated tumour with well developed fibrous connective tissue capsule. Histopathology of major salivary gland neoplasms sam j. To describe a salivary adenoma composed largely of unilayered ducts resembling striated ducts, and to differentiate it from similar adenomas, including canalicular and intercalated duct adenoma. These tumors have undergone taxonomic drift, with many terms used to describe these tumors over the years table 1. Previously, along with basal cell adenoma, ca was classified as a monomorphic adenoma. Canalicular adenoma canad is an uncommon benign salivary gland neoplasm.
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